Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S. J Biol Chem. 2005 Jul 15;280(28):26406-14.

CD39 reveals novel insights into the role of transmembrane domains in protein processing, apical targeting, and activity. Papanikolaou A, Papafotika A, Christoforidis S. Traffic. 2011 Sep;12(9):1148-65.

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis. Zografou S, Basagiannis D, Papafotika A, Shirakawa R, Horiuchi H, Auerbach D, Fukuda M, Christoforidis S. J Cell Sci. 2012 Oct 15;125(Pt 20):4780-90.

Exploring a Non-ATP Pocket for Potential Allosteric Modulation of PI3Kα. Gkeka P, Papafotika A, Christoforidis S, Cournia Z. J Phys Chem B. 2015 Jan 22;119(3):1002-16.

Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant. Gkeka P, Evangelidis T, Pavlaki M, Lazani V, Christoforidis S, Agianian B, Cournia Z. PLoS Comput Biol. 2014 Oct 23;10(10) .doi: 10.1371/journal.pcbi.1003895. eCollection 2014 Oct.

Discovery of new amino substituted pyrrolopyrimidines with antiproliferative activity against breast cancer cells and investigation of their effect towards the PI3Kα enzyme. Daniilides K, Lougiakis N, Evangelidis T, Kostakis IK, Pouli N, Marakos P, Mikros E, Skaltsounis AL, Bach S, Baratte B, Ruchaud S, Karamani V, Papafotika A, Christoforidis S, Argyros O, Kouvari E, Tamvakopoulos C. Anticancer Agents Med Chem. 2016 Dec 7, [Epub ahead of print].

Design and synthesis of novel 7-aminosubstituted pyrido[2,3-b]pyrazines exhibiting anti-breast cancer activity. Argyros O, Lougiakis N, Kouvari E, Papafotika A, Raptopoulou CP, Psycharis V, Christoforidis S, Pouli N, Marakos P, Tamvakopoulos C. Eur J Med Chem. 2017 Jan 27;126:954-968.

The orchestrated signaling by PI3Kα and PTEN at the membrane interface. Kotzampasi DM*, Premeti K*, Papafotika A*, Syropoulou V, Christoforidis S#, Cournia Z#, Leondaritis G#. Computational and Structural Biotechnology Journal (2022), doi: https://doi.org/10.1016/j.csbj.2022.10.007 *Equal contribution authors, #Equal corresponding authors.

Relevant patents

"A new assay to detect substances useful for the therapy of cancer and infectious diseases." European Patent Office - 99118385.6-2204.

"Assay to detect substances useful for therapy". United States Letters Patent, Serial Number 10/088,549, and Canadian Intellectual Property Office, CA 2384306, C12Q 1/44 (2006.01), 22/03/2001.

“Method of preparation and use of phosphoinositide 3-kinase inhibitors for cancerous diseases” 23.08.2019, PCT/EP2019/072648, European Patent Office.