Kostopoulou N, Bellou S, Bagli E, Markou M, Kostaras E, Hyvönen M, Kalaidzidis Y, Papadopoulos A, Chalmantzi V, Kyrkou A, Panopoulou E, Fotsis T, Murphy C. (2021) Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin A in differentiated cells. J Cell Sci. 134:jcs246892.

Papadopoulos A, Chalmantzi V, Mikhaylichenko O, Hyvönen M, Stellas D, Kanhere A, Heath J, Cunningham DL, Fotsis T, Murphy C. (2021) Combined transcriptomics and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells. Stem Cell Res. 50:102133.  

Markou M, Kouroupis D, Badounas F, Katsouras A, Kyrkou A, Fotsis T, Murphy C, Bagli E. (2020) Tissue Engineering Using Vascular Organoids From Human Pluripotent Stem Cell Derived Mural Cell Phenotypes. Front Bioeng Biotechnol. 8:278.

Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. (2016) Proteome changes during transition from human embryonic to vascular progenitor cells. J Proteome Res. 15:1995-2007.  
            
Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T. (2014) VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. Mol Cell. 54:559-72.

Publications since 2000

Kostopoulou N, Bellou S, Bagli E, Markou M, Kostaras E, Hyvönen M, Kalaidzidis Y, Papadopoulos A, Chalmantzi V, Kyrkou A, Panopoulou E, Fotsis T, Murphy C. (2021) Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin A in differentiated cells. J Cell Sci jcs.246892.
https://doi.org/10.1242/jcs.246892

Markou M, Kouroupis D, Fotsis T, Bagli E, Murphy C. Basic concepts in 3D Cell Culture. Book chapter: Vascularisation in 3D Cell Culture. 125-145. 2021. ISBN 978-3-030-66749-8.
https://doi.org/10.1007/978-3-030-66749-8

Chalmantzi V, Simitzi C, Papadopoulos A, Bagli E, Murphy C, Stratakis E, Fotsis T: Culturing human pluripotent stem cells on micropatterned silicon surfaces. Ms. No. SPRO-D-21-00036
Springer Protocols, accepted and in press June 2021.

Kougioumtzi A, Chatziathanasiadou M, Vrettos EI, Sayyad N, Sakka M, Stathopoulos P, Mantzaris MD , Ganai M, Karpoormath R, Vartholomatos G, Tsikaris V, Lazarides T, Murphy C, Tzakos AG:  Development of novel GnRH and Tat 48-60 based luminescent agents with enhanced cellular uptake and bioimaging properties. Dalton Transactions, 2021, DOI: 10.1039/D1DT00060H.

Vrettos E, Karampelas T., Sayyad N, Kougioumtzi A, Syed N, Crook T, Murphy C, Tamvakopoulos C, Tzakos A. Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable “click” oxime bond tethers and preclinical evaluation against prostate cancer. Eur. J. Medicinal Chem. 211 (2021) 113018.
https://www.sciencedirect.com/science/article/abs/pii/S0223523420309909

Papadopoulos A, Chalmantzi V, Mikhaylichenko O, Hyvönen M, Stellas D, Kanhere A, Heath J, Cunningham DL, Fotsis T, Murphy C. Supporting data on combined transcriptomics and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells. Data in Brief 35 (2021) 106844.
https://www.sciencedirect.com/science/article/pii/S2352340921001281

Papadopoulos A, Chalmantzi V, Mikhaylichenko O, Hyvönen M, Stellas D, Kanhere A, Heath J, Cunningham DL, Fotsis T, Murphy C. Combined transcriptomics and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells. Stem Cell Res 50 (2021) 102133.
https://pubmed.ncbi.nlm.nih.gov/33383406/

Markou M, Kouroupis D, Badounas F, Katsouras A, Kyrkou A, Fotsis T, Murphy C, Bagli E. Tissue Engineering Using Vascular Organoids From Human Pluripotent Stem Cell Derived Mural Cell Phenotypes. Frontiers in Bioengineering and Biotechnology (2020) doi: 10.3389/fbioe.2020.00278.
https://www.frontiersin.org/articles/10.3389/fbioe.2020.00278/full

Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis. J Cell Sci 129 (2016) 4091-4104.
https://www.ncbi.nlm.nih.gov/pubmed/27656109

Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. Proteome changes during transition from human embryonic to vascular progenitor cells. J Proteome Research 15 (2016) 1995-2007.
https://www.ncbi.nlm.nih.gov/pubmed/27146950

Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C: Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Research, 17 (2016) 458-460.
https://www.sciencedirect.com/science/article/pii/S1873506116300381

Kouroupis D, Kyrkou A, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A,  Georgoulis A, Murphy C, Fotsis T: Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Research 17 (2016) 448-457.
https://www.ncbi.nlm.nih.gov/pubmed/27217303

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T: ER mediates induction of endothelial cell survival and angiogenesis by VEGF: PLCg via mTORC1 activates ATF6 and PERK. Mol Cell 54 (2014) 559-72.
https://www.ncbi.nlm.nih.gov/pubmed/24746698

Kostaras E, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 at the crossroads of EGFR signalling and trafficking. Methods Enzymol 535 (2014) 225-47.
https://www.ncbi.nlm.nih.gov/pubmed/24377927

Bellou S, Pentheroudakis G, Murphy C, Fotsis T: Anti-angiogenesis in cancer therapy: Hercules and Hydra. Cancer Lett. 338 (2013) 291-28.
https://www.ncbi.nlm.nih.gov/pubmed/23707856

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 2013, 32:1831-1842.
https://www.ncbi.nlm.nih.gov/pubmed/22665057

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: The RhoD to centrosomal duplication. Small GTPases 2013, 4.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747252/

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 32 (2013) 5220-32.
https://www.ncbi.nlm.nih.gov/pubmed/23222715

Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T: The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth. Mol Cancer 2012, 11:35.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406996/

Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C: ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci 2011, 124:3209-3222.
https://www.ncbi.nlm.nih.gov/pubmed/21878490

Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T: VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. Am J Physiol Cell Physiol 2009, 297:C1477-1489.
https://www.ncbi.nlm.nih.gov/pubmed/19741200

Kardassis D, Murphy C, Fotsis T, Moustakas A, Stournaras C: Control of transforming growth factor beta signal transduction by small GTPases. FEBS J 2009, 276:2947-2965.
https://www.ncbi.nlm.nih.gov/pubmed/19490100

Murphy C: Endo-fin-ally a SARA for BMP receptors. J Cell Sci 2007, 120:1153-1155.

Fyhrquist P, Mwasumbi L, Vuorela P, Vuorela H, Hiltunen R, Murphy C, Adlercreutz H: Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines. Fitoterapia 2006, 77:358-366.
https://www.ncbi.nlm.nih.gov/pubmed/16797142

Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S: Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. J Biol Chem 2005, 280:26406-26414.
https://www.ncbi.nlm.nih.gov/pubmed/15890655

Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T: Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res 2005, 65:1877-1886.
https://www.ncbi.nlm.nih.gov/pubmed/15753386

Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T: Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res 2004, 64:7936-7946.
https://www.ncbi.nlm.nih.gov/pubmed/15520200

Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C, Fotsis T: Early endosomal regulation of Smad-dependent signalling in endothelial cells. J Biol Chem 2002, 277:18046-18052.
https://www.ncbi.nlm.nih.gov/pubmed/11877415

Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T: Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription. EMBO Rep 2002, 3:361-366.
https://www.ncbi.nlm.nih.gov/pubmed/11897665

Hatzi E, Murphy C, Zoephel A, Rasmussen H, Morbidelli L, Ahorn H, Kunisada K, Tontsch U, Klenk M, Yamauchi-Takihara K, et al.: N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth. Oncogene 2002, 21:3552-3561.
https://www.ncbi.nlm.nih.gov/pubmed/12032857

Hatzi E, Murphy C, Zoephel A, Ahorn H, Tontsch U, Bamberger AM, Yamauchi-Takihara K, Schweigerer L, Fotsis T: N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma. Eur J Biochem 2002, 269:3732-3741.
https://www.ncbi.nlm.nih.gov/pubmed/12153570

Murphy C, Saffrich R, Olivo-Marin JC, Giner A, Ansorge W, Fotsis T, Zerial M: Dual function of rhoD in vesicular movement and cell motility. Eur J Cell Biol 2001, 80:391-398.
https://www.ncbi.nlm.nih.gov/pubmed/11484930

Hatzi E, Breit S, Zoephel A, Ashman K, Tontsch U, Ahorn H, Murphy C, Schweigerer L, Fotsis T: MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human neuroblastoma cells. Purification, structural, and functional characterization. Adv Exp Med Biol 2000, 476:239-248.
https://www.ncbi.nlm.nih.gov/pubmed/10949669