Research

Chalkiadaki K., Statoulla E., Zafeiri M., Voudouri G., Amvrosiadis T., Typou A., Theodoridou N., Moschovas D., Avgeropoulos A., Samiotaki M., Mason J. O. and Gkogkas CG. (2024) GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2-/- cerebral organoids. Biological Psychiatry Global Open Science 2024 Nov 8 doi: https://doi.org/10.1101/2024.04.21.590378

Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, Coyle K, Harris Snell P, McGirr T, Sawant TN, Dang K, Stoichkova ZV, Azam Y, Saunders MP, Braun M, Alain T, Tuschl T, McDade SS, Longley DB, Gkogkas CG, Adrain C, Knight JRP, Jafarnejad SM. (2024) Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil. Nucleic Acids Res. doi: 10.1093/nar/gkae849

Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, Zhao HT, Fitzsimmons B, Gkogkas CG, Sonenberg N, Price TJ, Diatchenko L, Atlasi Y, Mogil JS, Khoutorsky A. (2024) Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. bioRxiv doi: 10.1101/2024.06.24.600539.

Wong C, Tavares-Ferreira D, Thörn Perez C, Sharif B, Uttam S, Amiri M, Lister KC, Hooshmandi M, Nguyen V, Séguéla P, Sonenberg N, Price TJ, Gkogkas CG* and Khoutorsky A.* (2023) 4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Sci Adv. doi: 10.1126/sciadv.adh9603. *co-last author

Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N*, Gkogkas CG*, Khoutorsky A*. (2023) Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron doi: 10.1016/j.neuron.2023.06.017 *co-last author

Chalkiadaki K., Statoulla E., Zafeiri M., Haji N., Lacaille J.C., Powell C.M., Jafarnejad S.M., Khoutorsky A., Gkogkas C. G. (2023) Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1. Front Cell Dev Biol doi: 10.3389/fcell.2023.1205112

Patil S, Chalkiadaki K, Mergiya TF, Krimbacher K, Amorim IS, Akerkar S, Gkogkas CG*, Bramham CR*. (2023) eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience doi: 10.1016/j.isci.2023.106649

Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS. (2023) Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association J Neurosci doi: 10.1523/JNEUROSCI.1002-22.2023

Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM, Khoutorsky A and Gkogkas C. G. (2020) Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling. Prog Neurobiol 101903. doi: 10.1016/j.pneurobio.2020.101903.

Atlasi Y, Jafarnejad SM, Gkogkas C. G., Vermeulen M, Sonenberg N, Stunnenberg HG. (2020) The translational landscape of ground state pluripotency Nat Commun 11(1):1617. doi: 10.1038/s41467-020-15449-9

Hoang HD, Graber TE, Jia JJ, Vaidya N, Gilchrist VH, Xiang X, Li W, Cowan KN, Gkogkas C. G., Jaramillo M, Jafarnejad SM, Alain T. (2019) Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection. Cell Rep 29(12):4010-4023.e5. doi: 10.1016/j.celrep.2019.11.072

Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A and Gkogkas C. G. (2019) Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep 29(11):3620-3635.e7. doi: 10.1016/j.celrep.2019.11.023

Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A and Gkogkas C. G. (2019) Monitoring translation in synaptic fractions using a ribosome profiling strategy. J Neurosci Methods. 329:108456. doi: 10.1016/j.jneumeth.2019.108456

Amorim IS, Lach G and Gkogkas CG. (2018) The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders. Front Genet. 9:561. doi: 10.3389/fgene.2018.00561

Uttam, S., Wong, C, Amorim, I. S., Jafarnejad, S. M., Tansley, S., Yang, J., Prager-Khoutorsky, M., Mogil, J. S., Gkogkas, C. G.* and Khoutorsky, A.* (2018) Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of pain 4:35-44. doi: 10.1016/j.ynpai.2018.04.001

Amorim I.S., Kedia S., Kouloulia S., Simbriger K., Gantois I., Jafarnejad S. M., Li Y., Kampaite A., Pooters T., Romanò N and Gkogkas C. G. (2018) Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation. The Journal of neuroscience : the official journal of the Society for Neuroscience 21 38(8):2118-2133. doi: 10.1523/JNEUROSCI.2673-17.2018

Jafarnejad, S. M., Chapat, C., Matta-Camacho, E., Gelbart, I. A., Hesketh, G. G., Arguello, M., Garzia, A., Kim, S. H., Attig, J., Shapiro, M., Morita, M., Khoutorsky, A., Alain, T., Gkogkas, C., Stern-Ginossar, N., Tuschl, T., Gingras, A. C., Duchaine, T (2018) Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife 7 doi: 10.7554/eLife.35034

Martin, L. J., Smith, S. B., Khoutorsky, A., Magnussen, C. A., Samoshkin, A., Sorge, R. E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khuong, T. M., Mir, E., Gibson, D. G., Wieskopf, J. S., Sotocinal, S. G., Austin, J. S., Meloto, C. B., Gitt, J. H., Gkogkas, C., Sonenberg, N., Greenspan, J. D., Fillingim, R. B., Ohrbach, R., Slade, G. D., Knott, C., Dubner, R., Nackley, A. G., Ribeiro-da-Silva, A., Neely, G. G., Maixner, W., Zaykin, D. V., Mogil, J. S. & Diatchenko, L. (2017) Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest 127 3353-3366. doi: 10.1172/JCI87406

Moy, J. K., Khoutorsky, A., Asiedu, M. N., Black, B. J., Kuhn, J. L., Barragan-Iglesias, P., Megat, S., Burton, M. D., Burgos-Vega, C. C., Melemedjian, O. K., Boitano, S., Vagner, J., Gkogkas, C. G., Pancrazio, J. J., Mogil, J. S., Dussor, G., Sonenberg, (2017) he MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017

Gantois, I., Khoutorsky, A., Popic, J., Aguilar-Valles, A., Freemantle, E., Cao, R., Sharma, V., Pooters, T., Nagpal, A., Skalecka, A., Truong, V. T., Wiebe, S., Groves, I. A., Jafarnejad, S. M., Chapat, C., McCullagh, E. A., Gamache, K., Nader, K., Lacaille, J. C., Gkogkas, C. G.* & Sonenberg, N.* (2017) Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature medicine 23 674-677. doi: 10.1038/nm.4335

Tuttle, A. H., Tansley, S., Dossett, K., Tohyama, S., Khoutorsky, A., Maldonado-Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., Sukosd, M., Leger, P., Hardt, O. M., Yachnin, D., Austin, J. S., Chan, C. M., Pooters, T., Groves, I., Martin, L. J., Sonenberg, N., Gkogkas, C. G.* & Mogil, J. S.* (2017) Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. Proceedings of the National Academy of Sciences of the United States of America 114 5515-5520. doi: 10.1073/pnas.1703477114

Chapat, C., Jafarnejad, S. M., Matta-Camacho, E., Hesketh, G. G., Gelbart, I. A., Attig, J., Gkogkas, C. G., Alain, T., Stern-Ginossar, N., Fabian, M. R., Gingras, A. C., Duchaine, T. F. & Sonenberg, N. (2017) Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences of the United States of America 114, 5425-5430. doi: 10.1073/pnas.1701488114

Tahmasebi S., Jafarnejad S. M., Tam I. S., Gonatopoulos-Pournatzis T., Matta-Camacho E., Tsukumo Y., Yanagiya A., Li W., Atlasi Y., Caron M., Braunschweig U., Pearl D., Khoutorsky A., Gkogkas C. G., Nadon R., Bourque G., Yang X. J., Tian B., Stunnenberg H (2016) Control of embryonic stem cells self-renewal and differentiation via coordinated splicing and translation of YY2. PNAS doi: 10.1073/pnas.1615540113

Khoutorsky, A., Sorge R.E., Prager-Khoutorsky M., Pawlowski S. A., Longod G., Jafarnejad S. M., Tahmasebi S., Martin L., Pitchere M. H., Gkogkas C. G., Sharif-Naeinig R., Alfredo Ribeiro-da-Silvad A., Bourque C. W., Cerveroh F., Mogil J. S., & Sonenberg N (2016) eIF2alpha phosphorylation controls thermal nociception PNAS doi: 10.1073/pnas.1614047113

Skalecka, A., Liszewska, E., Bilinski, R., Gkogkas, C., Khoutorsky, A., Malik, A. R., Sonenberg, N. & Jaworski, J. (2016) mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons Dev Neurobiol doi: 10.1002/dneu.22392

Khoutorsky, A., Bonin, R. P., Sorge, R. E., Gkogkas, C. G., Pawlowski, S. A., Jafarnejad, S. M., Pitcher, M. H., Alain, T., Perez-Sanchez, J., Salter, E. W., Martin, L., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil, J. S. & Sonenberg, N. (2015) Translational control of nociception via 4E-binding protein 1 Elife 4 doi: 10.7554/eLife.12002

Maity, S., Rah, S., Sonenberg, N., Gkogkas, C. G. & Nguyen, P. V. (2015) Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learn Mem 22 499-508. doi: 10.1101/lm.039222.115

Aguilar-Valles, A., Matta-Camacho, E., Khoutorsky, A., Gkogkas, C., Nader, K., Lacaille, J. C. & Sonenberg, N. (2015) Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. The Journal of neuroscience : the official journal of the Society for Neuroscience 35 11125-11132. doi: 10.1523/JNEUROSCI.4615-14.2015

Cao, R., Gkogkas, C. G., de Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. (2015) Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18 855-862. doi: 10.1038/nn.4010

Aulas, A., Caron, G., Gkogkas, C. G., Mohamed, N. V., Destroismaisons, L., Sonenberg, N., Leclerc, N., Parker, J. A. & Vande Velde, C. (2015) G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. J Cell Biol 209 73-84. doi: 10.1083/jcb.201408092

Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., Konicek, B. W., Graff, J. R., Tzinia, A. K., Lacaille, J. C. & Sonenberg, N. (2014) Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes Cell reports 9 1742-1755. doi: 10.1016/j.celrep.2014.10.064

Jung, H., Gkogkas, C. G., Sonenberg, N. & Holt, C. E. (2014) Remote control of gene function by local translation. Cell 157 26-40. doi: 10.1016/j.cell.2014.03.005

Tahmasebi, S., Alain, T., Rajasekhar, V. K., Zhang, J. P., Prager-Khoutorsky, M., Khoutorsky, A., Dogan, Y., Gkogkas, C. G., Petroulakis, E., Sylvestre, A., Ghorbani, M., Assadian, S., Yamanaka, Y., Vinagolu-Baur, J. R., Teodoro, J. G., Kim, K., Yang, X. J. & Sonenberg, N. (2014) Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell 14 606-616. doi: 10.1016/j.stem.2014.02.005

Gkogkas, C. G. & Sonenberg, N. (2013) Translational control and autism-like behaviors. Cell Logist 3 e24551. doi: 10.4161/cl.24551

Cao, R., Robinson, B., Xu, H., Gkogkas, C., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S. & Sonenberg, N. (2013) Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79 712-724. doi: 10.1016/j.neuron.2013.06.026

Khoutorsky, A., Gkogkas, C. G.*, Yanagiya, A.*, Fabian, M. R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R. E., Mogil, J. S., Nader, K., Lacaille, J. C. & Sonenberg, N. (2013) Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron 78 298-311. doi: 10.1016/j.neuron.2013.02.025

Ran, I., Gkogkas, C. G., Vasuta, C., Tartas, M., Khoutorsky, A., Laplante, I., Parsyan, A., Nevarko, T., Sonenberg, N. & Lacaille, J. C. (2013) Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 33 1872-1886. doi: 10.1523/JNEUROSCI.3264-12.2013

Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., Major, F., Lasko, P., Ruggero, D., Nader, K., Lacaille, J. C. & Sonenberg, N. (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 371-377. doi: 10.1038/nature11628

Chua, J. J., Schob, C., Rehbein, M., Gkogkas, C. G., Richter, D. & Kindler, S. (2012) Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. Sci Rep 2 484. doi: 10.1038/srep00484

Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W. C. & Sonenberg, N. (2011) mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol 12 235-245. doi: 10.1038/nrm3083

Gkogkas, C., Wardrope, C., Hannah, M. & Skehel, P. (2011) The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons. J Neurochem 117 286-294. doi: 10.1111/j.1471-4159.2011.07201.x

Gkogkas, C., Sonenberg, N. & Costa-Mattioli, M. (2010) Translational control mechanisms in long-lasting synaptic plasticity and memory J Biol Chem 285 31913-31917. doi: 10.1074/jbc.R110.154476

Bidinosti, M., Ran, I., Sanchez-Carbente, M. R., Martineau, Y., Gingras, A. C., Gkogkas, C., Raught, B., Bramham, C. R., Sossin, W. S., Costa-Mattioli, M., DesGroseillers, L., Lacaille, J. C. & Sonenberg, N. (2010) Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell 37 797-808. doi: 10.1016/j.molcel.2010.02.022

Rampakakis, E., Gkogkas, C., Di Paola, D. & Zannis-Hadjopoulos, M. (2010) Replication initiation and DNA topology: The twisted life of the origin. J Cell Biochem 110 35-43. doi: 10.1002/jcb.22557

Gkogkas, C., Middleton, S., Kremer, A. M., Wardrope, C., Hannah, M., Gillingwater, T. H. & Skehel, P. (2008) VAPB interacts with and modulates the activity of ATF6 Hum Mol Genet 17 1517-1526. doi: 10.1093/hmg/ddn040

Gkogkas, C. G.*, Vernikos, G. S.*, Promponas, V. J. & Hamodrakas, S. J. (2003) GeneViTo: visualizing gene-product functional and structural features in genomic datasets. BMC Bioinformatics 4 53. doi: 10.1186/1471-2105-4-53

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