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    Sofia Bellou

    Sofia Bellou

    Senior Research Scientist

    Foundation for Research & Technology-Hellas
    Institute of Molecular Biology & Biotechnology
    Dep. of Biomedical Research
    University Campus of Ioannina
    45 115 Ioannina, Greece

    Phone : +30 26510 07816

    Email address
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    B.Sc in Physics, 2000 (University of Ioannina)
    M.Sc in Applied Biomolecular Technology, 2002 (University of Nottingham, U.K.)
    Ph.D in Biological Chemistry, 2008 (University of Ioannina)
    Current position: Head of Confocal Laser Scanning Microscopy Unit, Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, University of Ioannina, Greece
    Biomedical Research Division, Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Ioannina, Greece

    PUBLICATIONS (Citations: 605, h-index: 9)
    1. Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin A in differentiated cells.
    Kostopoulou N*, Bellou S*, Bagli E, Markou M, Kostaras E, Hyvönen M, Kalaidzidis Y, Papadopoulos A, Chalmantzi V, Kyrkou A, Panopoulou E, Fotsis T, Murphy C.
    J Cell Sci. 2021 Jul 1;134(13):jcs246892. doi: 10.1242/jcs.246892. Joint first author.

    2. Biotin-Yellow a biotin guided NIR turn-on fluorescent probe for cancer targeted diagnosis
    Dimitrios A Diamantis, Adamantia Agalou, Maria V Chatziathanasiadou, Georgios S Markopoulos, Sofia Bellou, Zoi Kanaki, Timothy Crook, Nelofer Syed, Theodoros Rampias, Apostolos Klinakis, Evangelos Kolettas, Dimitris Beis, Andreas G Tzakos Sensors and Actuators B Chemical 337 (2021). DOI: 10.1016/j.snb.2021.129807.
    3. Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation
    Maria V. Chatziathanasiadou, Elena G. Geromichalou, Nisar Sayyad, Eirinaios I. Vrettos, Antigoni Katsikoudi, Evgenios Stylos, Sofa Bellou, George D. Geromichalos, Andreas G. Tzakos
    Amino Acids. 2017 Nov 28. doi: 10.1007/s00726-017-2514-2

    4. Retrotransposon expression and incorporation of cloned human and mouse retroelements in human spermatozoa.
    Lazaros L, Kitsou C, Kostoulas C, Bellou S, Hatzi E, Ladias P, Stefos T, Markoula S, Galani V, Vartholomatos G, Tzavaras T, Georgiou I.
    Fertil Steril. 2017 Mar;107(3):821-830. doi: 10.1016/j.fertnstert.2016.12.027.

    5. Exogenous retroelement integration in sperm and embryos affects preimplantation development.
    Kitsou C, Lazaros L, Bellou S, Vartholomatos G, Sakaloglou P, Hatzi E, Markoula S, Zikopoulos K, Tzavaras T, Georgiou I.
    Reproduction. 2016 Sep;152(3):185-93. doi: 10.1530/REP-15-0174.

    6. Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis.
    Mantzaris MD, Bellou S, Skiada V, Kitsati N, Fotsis T, Galaris D.
    Free Radic Biol Med. 2016 Aug;97:454-65. doi: 10.1016/j.freeradbiomed.2016.07.002.

    7. DNA-histone complexes as ligands amplify cell penetration and nuclear targeting of anti-DNA antibodies via energy-independent mechanisms.
    Zannikou M, Bellou S, Eliades P, Hatzioannou A, Mantzaris MD, Carayanniotis G, Avrameas S, Lymberi P.
    Immunology. 2016 Jan;147(1):73-81. doi: 10.1111/imm.12542. Epub 2015 Nov 24.

    8. VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis.
    Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T.
    Cell Oncol. 2014 Dec 23;1(3):e964024. doi: 10.4161/23723548.2014.964024.
    9. VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.
    Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T.
    Mol Cell. 2014 May 22;54(4):559-72. doi: 10.1016/j.molcel.2014.03.022. Epub 2014 Apr 17.

    10. Anti-angiogenesis in cancer therapy: Hercules and hydra.
    Bellou S, Pentheroudakis G, Murphy C, Fotsis T.
    Cancer Lett. 2013 Sep 28;338(2):219-28. doi: 10.1016/j.canlet.2013.05.015. Epub 2013 May 21. Review.

    11. Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment - an evolutionary perspective.
    Tsatsoulis A, Mantzaris MD, Bellou S, Andrikoula M.
    Metabolism. 2013 May;62(5):622-33. doi: 10.1016/j.metabol.2012.11.004. Epub 2012 Dec 20. Review.

    12. The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth.
    Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T.
    Mol Cancer. 2012 May 14;11:35. doi: 10.1186/1476-4598-11-35.

    13. Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility.
    Stoyianni A, Goussia A, Pentheroudakis G, Siozopoulou V, Ioachim E, Krikelis D, Golfinopoulos V, Cervantes A, Bobos M, Fotsis T, Bellou S, Fountzilas G, Malamou-Mitsi V, Pavlidis N.
    Anticancer Res. 2012 Apr;32(4):1273-81.

    14. VEGF Auto-Regulates Its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades By Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells.
    Sofia Bellou, Mark A Hink, Eleni Bagli, Ekaterini Panopoulou, Philippe I H Bastiaens, Carol Murphy, Theodore Fotsis
    Am J Physiol Cell Physiol, December 2009 vol. 297, no.6,C1477-C1489