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    Eleni Bagli

    Eleni Bagli

    Senior Research Scientist

    Foundation for Research & Technology-Hellas
    Institute of Molecular Biology & Biotechnology
    Dep. of Biomedical Research
    University Campus of Ioannina
    45 115 Ioannina, Greece

    Phone : +30 26510 07816

    Email address
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    MD, University of Ioannina Greece
    PhD, University of Ioannina, Greece
    Certified Board Ophthalmologist

    Professional Experience
    - Research Scientist 1 in the Pharmacology Department, Exelixis inc. South San Francisco, CA, USA (2004)
    - Clinical Research Fellow in Medical Retina service -Moorfields Eye Hospital, London, UK (2009)
    - Senior Research Scientist in FORTH/IMBB-BR (from 2011)
    - Consultant ophthalmologist in the University Eye clinic of Ioannina (from 2016) with a focus on medical retina.

    Research Interests
    Her research interests include the differentiation of human pluripotent stem cells to vascular cells (endothelial and mural cells) and the generation of organoid-like platforms that can be applied to drug development and various tissue engineering applications. She has 29 publications, 1886 citations and h-factor of 16.

    1. Kotanidou A, Xagorari A, Bagli E, Kitsanta P, Fotsis T, Papapetropoulos A, Roussos C.
    Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice.
    American Journal of Respiratory & Critical Care Medicine. 2002 Mar 15;165(6):818-23.

    2. Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T.
    Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity.
    Cancer Research. 2004 Nov 1;64(21):7936-46.

    3. Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T.
    Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms.
    Cancer Research. 2005 Mar 1;65(5):1877-86.

    4. Tsanou E, Ioachim E, Stefaniotou M, Gorezis S, Charalabopoulos K, Bagli E, Peschos D, Psilas K, Agnantis NJ.
    Immunohistochemical study of angiogenesis and proliferative activity in epiretinal membranes.
    International Journal of Clinical Practice. 2005 Oct;59(10):1157-61.

    5. Bellou S, Hink M, Bagli E, Panopoulou E, Bastiaens P, Murphy C, Fotsis T.
    VEGF Auto-regulates its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades by Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells.
    American Journal of Physiology Cell Physiology. 2009 Dec;297(6):C1477-89.

    6. Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T.   The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth.
    Mol  Cancer. 2012 May 14;11:35.

    7. Bagli E, Tsolis KC, Kanaki K, Zografou S, Carpentier S, Bei ES, Christoforidis S, Zervakis M, Murphy  C, Fotsis T, Economou A. Proteome Changes during Transition from Human Embryonic to Vascular Progenitor Cells.
     J Proteome Res. 2016 Jun 3;15(6):1995-2007.
    8. Bagli E, Goussia A, Moschos MM, Agnantis N, Kitsos G. Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems.
    In Vivo. 2016 09-10;30(5):535-47.

    9. Vlaikou AM, Kouroupis D, Sgourou A, Markopoulos GS, Bagli E, Markou M, Papadopoulou Z, Fotsis T, Nakos G, Lekka ME, Syrrou M. Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs.
    Biochim Biophys Acta Mol Cell Res. 2017 Aug;1864(8):1371-1381.

    10. Bagli E, Zikou AK, Agnantis N, Kitsos G. Mitochondrial Membrane Dynamics and Inherited Optic Neuropathies. In Vivo. 2017 Jul-Aug;31(4):511-525.

    11. Kolettis TM, Bagli E, Barka E, Kouroupis D, Kontonika M, Vilaeti AD, Markou M, Roumpi M, Maltabe  V, La Rocca V, Agathopoulos S, Fotsis T. Medium-term Electrophysiologic Effects of a Cellularized Scaffold Implanted in Rats After Myocardial  Infarction.
    Cureus. 2018 Jul 10;10(7):e2959.

    12. Christodoulou A, Bagli E, Gazouli M, Moschos MM, Kitsos G. Genetic polymorphisms associated with the prevalence of retinal vein occlusion in a Greek population.  
    Int Ophthalmol. 2019 Nov;39(11):2637-2648.

    13. Chatziralli I, Dimitriou E, Theodossiadis G, Bourouki E, Bagli E, Kitsos G, Theodossiadis P. Intravitreal ranibizumab versus vitrectomy for recurrent vitreous haemorrhage after pars plana vitrectomy   for proliferative diabetic retinopathy: a prospective study.
    Int Ophthalmol. 2020 Apr;40(4):841-847.

    14. Markou M, Kouroupis D, Badounas F, Katsouras A, Kyrkou A, Fotsis T, Murphy C*, Bagli E*.Tissue Engineering Using Vascular Organoids From Human Pluripotent Stem Cell Derived Mural Cell  Phenotypes. Front Bioeng Biotechnol. 2020 Apr 17;8:278.

    15. Christodoulou A, Bagli E*, Gazouli M, Moschos MM, Kitsos G. Association of MMP2-1306C/T Polymorphism with Ischemic Retinal Vein Occlusion.
    Arch Med Res. 2020 Oct;51(7):710-713.

    16. GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.  
    Lancet Glob Health. 2021 Feb;9(2):e144-e160.

    17. GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021 Feb;9(2):e130-e143.

    18. Xydias D, Ziakas G, Psilodimitrakopoulos S, Lemonis A, Bagli E, Fotsis T, Gravanis A, Tzeranis DS,  Stratakis E. Three-dimensional characterization of collagen remodeling in cell-seeded collagen scaffolds via  polarization second harmonic generation.   
    Biomed Opt Express. 2021 Jan 28;12(2):1136-1153.

    19. Kostopoulou N, Bellou S, Bagli E, Markou M, Kostaras E, Hyvönen M, Kalaidzidis Y, Papadopoulos A,  Chalmantzi V, Kyrkou A, Panopoulou E, Fotsis T, Murphy C.Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin A in differentiated  cells.
    J. Cell Sci., 134 (13). (2021).