Research in The Fotsis and Murphy labs is focused on two main research questions. The first concerns the molecular mechanisms regulating Angiogenesis and Vasculogenesis. The second research area involves the role of the endocytic pathway in growth factor signaling. We study the role of TGFβ family members (TGFβ, Activin A and BMP4) and VEGF in endothelial cells. We also investigate trafficking and signaling during pluripotency and differentiation using human embryonic stem cells and human induced pluripotent stem cells and are interested in the role of endocytic trafficking during stem cell differentiation. Finally, we use human embryonic stem cells, human induced pluripotent stem cells and mature primary endothelial cells for translational targets related to tumour angiogenesis and regenerative medicine.