2026
- Papageorgiou MP, Nussbaumer M, Samiotaki M, Filiou MD (2026) Basal anxiety levels shape hippocampal responses to acute stress in high anxiety mice. J Neurochem (in press)
2025
- Vlaikou AM, Nussbaumer M, Iliou A, Papageorgiou MP, Komini C, Theodorisou D, Benaki D, Gikas E, Syrrou M, Filiou MD (2025) Early life stress induces brain mitochondrial dynamics changes and sex-specific adverse effects in adulthood. J Neurosci Res 103:e70023.
- Theodoridou D, Tsiantis CO, Marcozannes G, Chondrou V, Vlaikou AM, Karampas A, Georgiou G, Filiou MD, Syrrou M, Petrikis P (2025) mRNA levels of HPA axis mediators in drug-naive First Episode Psychosis patients before and after antipsychotic treatment. Int J Psychiatry Clin Pract 29:209-21.
- Panara A, Biliraki D, Nussbaumer M, Filiou MD, Thomaidis NS, Kostakis IK, Gikas E. (2025) LC-MS/MS method development and validation for the determination of a new mitochondrial antioxidant in liver and cerebellum of mice employing advanced chemometrics. Molecules 2025 30:1900.
2024
- Papageorgiou M#, Filiou MD#. (2024) Mitochondria dynamics and psychiatric disorders: The missing link. Neurosci Biobehav Rev 165:105837.
- Messinis A*, Panteli E*, Paraskevopoulou A*, Zymarikopoulou AK*, Filiou MD#. (2024) Altered lipidomics biosignatures in schizophrenia: a systematic review. Schizophr Res 271:280-290.
- Thomou C*, Nussbaumer M*, Grammenou E*, Komini C, Vlaikou AM, Papageorgiou MP, Filiou MD#. (2024) Early handling exerts anxiolytic effects and alters brain mitochondrial dynamics in adult high anxiety mice. Mol Neurobiol 61:10593-612.
- Barreto-Domingos L, Müller-Kaastrup H, Rodrigues da Silva N, Filiou MD#, Nielsen AL, Silveira Guimarães F, Wegerer G, Joca S. (2024) Cannabidiol effects on neuroplasticity markers and lipidome in the prefrontal cortex of a rat model fo depression. Neuropharmacology 248:109870.
- Theodoridou D, Tsiantis CO, Vlaikou AM, Chondrou V, Zakopoulou V, Christodoulides P, Oikonomou ED, Tzimourta KD, Kοstoulas C, Tzallas AT, Tsamis KI, Peschos D, Sgourou A, Filiou MD#, Syrrou M. (2024) Developmental dyslexia: insights from ΕEG-based findings and molecular signatures-a pilot study. Brain Sci 14:139.
- Papageorgiou MP*, Theodoridou D*, Nussbaumer M, Syrrou M, Filiou MD#. (2024) Deciphering the metabolome under stress: Insights from rodent models Curr Neuropharmacol 22:884-903.
2022
- Filiou MD#, Teplytska L, Nussbaumer M, Otte DM, Zimmer A, Turck CW. (2022) Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice. J Pers Med. 12:244.
- Turck CW#, Webhofer C, Reckow S, Moy J, Wang M, Guillermier C, Poczatek JC, Filiou MD#. (2022) Antidepressant treatment effects on hippocampal protein turnover: Molecular and spatial insights from mass spectrometry. Proteomics. 22: e2100244.
2021
- Iliou A*, Vlaikou AM*, Nussbaumer M, Benaki D, Mikros E, Gikas E, Filiou MD#. (2021) Exploring the metabolomic profile of cerebellum after exposure to acute stress. Stress 24:952-964.
- Vlaikou AM, Nussbaumer M, Komini C, Lambrianidou A, Konidaris C, Trangas T#, Filiou MD#. (2021) Exploring the crosstalk of glycolysis and mitochondrial metabolism in psychiatric disorders and brain tumors Eur J Neurosci. 53:3002-3018.
- Filiou MD#, Nussbaumer M, Teplytska L, Turck CW#. (2021) Behavioral and Metabolome Differences between C57BL/6 and DBA/2 Mouse Strains: Implications for Their Use as Models for Depression- and Anxiety-Like Phenotypes. Metabolites 11:128.
2020
- Chousidis I, Chatzimitakos T, Leonardos D, Filiou MD#, Stalikas CD, Leonardos ID. (2020) Cannabinol in the spotlight: Toxicometabolomic study and behavioral analysis of zebrafish embryos exposed to the unknown cannabinoid. Chemosphere 252:126417.
2019
- Weckmann K, Deery MJ, Howard JA, Feret R, Asara JM, Dethloff F, Filiou MD#, Labermaier C, Maccarrone G, Lilley KS, Müller M, Turck CW. (2019) Ketamine’s effects on the glutamatergic and GABAergic systems - a proteomics and metabolomics study in mice. Mol Neuropsychiatry 5:42-51.
- Papadopoulou Z, Vlaikou AM, Theodoridou D, Komini C, Chalkiadaki G, Vafeiadi M, Margetaki K, Trangas T, Turck CW, Syrrou M*, Chatzi L*, Filiou MD*,#. (2019) Unraveling the Serum Metabolomic Profile of Post-partum Depression. Front Neurosci 13:833.
- Filiou MD#, Sandi C#. (2019) Anxiety and Brain Mitochondria: A Bidirectional Crosstalk. Trends Neurosci 42:573-588.
- Papadopoulou Z, Vlaikou AM, Theodoridou D, Markopoulos GS, Tsoni K, Agakidou E, Drosou-Agakidou V, Turck CW, Filiou MD#, Syrrou M#. (2019) Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events. Front Psychiatry 10:220.
2017
- Maccarrone G, Chen A, Filiou MD#. (2017) Using 15N metabolic labeling for quantitative proteomic analyses. Methods Mol Biol 1546:235-43.
- Weckmann K, Deery MJ, Howard JA, Feret R, Asara JM, Dethloff F, Dethloff F, Filiou MD#, Lannace J, Labermaier C, Maccarrone G, Webhofer C, Teplytska L, Lilley K, Müller M, Turck CW. (2017) Ketamine's antidepressant effect is mediated by energy metabolism and antioxidant defense system. Sci Rep 7:15788.
- Filiou MD#, Banati RB, Graeber MB#. (2017) The mitochondrial 18-kDa translocator protein (TSPO) as a CNS drug target: Finding our way through the neuroinflammation fog. CNS and Neurological Disorders - Drug Targets 16:990-9.
- Gikas E#, Filiou M#. (2017) Mass spectrometry and the Mediterranean. J Chromatogr B Analyt Technol Biomed Life Sci 1047:1 (Editorial).
- Park DI, Dournes C, Sillaber I, Asara JM, Ising M, Webhofer C, Filiou MD#, Müller MB, Turck CW. (2017) Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems. Transl Psychiatry 7:e1078.
- Lopes S, Teplytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Maccarrone G, Almeida OF, Turck CW, Sousa N, Sotiropoulos I#, Filiou MD#. (2017) Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: Role of synaptic mitochondria. Cereb Cortex 27:2580-91.
2016
- Turck CW, Webhofer C, Nussbaumer M, Teplytska L, Chen A, Maccarrone G, Filiou MD#. (2016) Stable isotope metabolic labeling suggests differential turnover of the DPYSL protein family. Proteomics Clin Appl 10:1269-72.
- Nussbaumer M, Asara JM, Teplytska L, Murphy MP, Logan A, Turck CW, Filiou MD#. (2016) Selective mitochondrial targeting exerts anxiolytic effects in vivo. Neuropsychopharmacology 41:1751-8.
- Park DI*, Dournes C*, Sillaber I, Uhr M, Asara JM, Gassen NC, Rein T, Ising M, Webhofer C, Filiou MD#, Müller MB, Turck CW. (2016) Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant response in mice and humans. Sci Rep 6:35317.
- Kao CY, He Z, Henes K, Asara JM, Webhofer C, Filiou MD#, Khaitovich P, Wotjak CT, Turck CW. (2016) Fluoxetine treatment rescues energy metabolism pathway alterations in a posttraumatic stress disorder mouse model. Mol Neuropsychiatry 2:46-59.
2015
- Maccarrone G, Filiou MD#. (2015) Protein profiling and phosphoprotein analysis by IEF. Methods Mol Biol 1295:293-303.
- Filiou MD#, Soukupova M, Rewerts C, Webhofer C, Turck CW, Maccarrone G. (2015) Variability assessment of 15N metabolic labeling-based proteomics workflow in mouse brain and plasma. Mol Biosyst 11:1536-42.
- Filiou MD#. (2015) Can proteomics-based diagnostics aid clinical psychiatry? Proteomics Clin Appl 9:885-8.
- Turck CW, Filiou MD#. (2015) What have proteomics and metabolomics (not) taught us about psychiatric disorders? Mol Neuropsychiatry 1:69-75.
2014
- Wood PL, Filiou MD#, Otte DM, Zimmer A, Turck CW. (2014) Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse. Schizophrenia Res 159:365-9.
- Filiou MD#, Moy J, Wang M, Guillermier C, Poczatek C, Turck C, Lechene C. (2014) Effect of an anti-depressant on mouse hippocampus protein turnover using MIMS. Surf Interface Anal 46:S144-6 (Conference paper).
- Filiou MD#, Asara JM, Nussbaumer M, Teplytska L, Landgraf R, Turck CW. (2014) Metabolic profiles of behavioral extremes in trait anxiety. J Psychiatr Res 58:115-22.
- Iris F, Filiou M#, Turck CW. (2014) Differential proteomics analyses reveal anxiety-associated molecular and cellular mechanisms in cingulate cortex synapses. Am J Psychiatry Neurosci 2:25-42.
- Filiou MD#, Arefin AS, Moscato P, Graeber MB. (2014) Neuroinflammation’ differs categorically from inflammation: transcriptomes of Parkinson’s disease, Alzheimer’s disease, schizophrenia and inflammatory diseases compared. Neurogenetics 15:201-12.
2013
- Webhofer C*, Zhang Y*, Brusis J, Reckow S, Landgraf R, Maccarrone G, Turck CW, Filiou MD#. (2013) 15N metabolic labeling: evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times. J Proteomics 2013 88:27-33.
- O'Neil SE, Palviainen MJ, Ten Have S, Filiou M# Gonzalez A, Hodge K, Surinova S, Penque D, Baker MS. (2013) Clinical proteomics stretch goals: EuPA 2012 roundtable report. J Proteomics 88:37-40.
- Filiou MD#. (2013) The potential of 15N metabolic labeling for schizophrenia research. Arch Clin Psychiatry 40:51-2.
2012
- Filiou MD#, Martins-de-Souza D, Guest PC, Bahn S, Turck CW. (2012) To label or not to label: Applications of quantitative proteomics in neuroscience research. Proteomics 12:736-47.
- Filiou MD#, Turck CW. (2012) Psychiatric disorder biomarker discovery using quantitative proteomics. Methods Mol Biol 829:531-9.
- Filiou MD#, Teplytska L, Otte DM, Zimmer A, Turck CW. (2012) Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model. J Psychiatr Res 46:1359-65.
- Filiou MD*, Webhofer C*, Gormanns P*, Zhang Y, Bisle B, Teplytska L, Frank E, Kessler MS, Maccarrone G, Landgraf R, Turck CW. (2012) The 15N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model. Proteomics 12:2421-7.
- Filiou MD#, Varadarajulu J, Teplytska L, Reckow S, Maccarrone G, Turck CW. (2012) The 15N isotope effect in Escherichia coli: A neutron can make the difference. Proteomics 12:3121-8.
2011
- Filiou MD#, Turck CW. (2011) General overview: Biomarkers in neuroscience research. Int Rev Neurobiol 101:1-17.
- Zhang Y, Filiou MD#, Reckow S, Gormanns P, Maccarrone G, Kessler MS, Frank E, Hambsch B, Holsboer F, Landgraf R, Turck CW. (2011) Proteomic and metabolomic profiling of a trait anxiety mouse model implicates affected pathways. Mol Cell Proteomics 10:M111.008110.
- Filiou MD#, Zhang Y, Teplytska L, Reckow S, Gormanns P, Maccarrone G, Frank E, Kessler MS, Hambsch B, Nussbaumer M, Bunck M, Ludwig T, Yassouridis A, Holsboer F, Landgraf R, Turck CW. (2011) Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. Biol Psychiatry 70:1074-82.
- Otte DM, Sommersberg B, Kudin A, Guerrero C, Albayram Ö, Filiou MD#, Frisch P, Yilmaz Ö, Drews E, Turck CW, Bilkei-Gorzó A, Kunz WS, Beck H, Zimmer A. (2011) N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology 36:2233-43.
- Filiou MD#, Turck CW, Martins-de-Souza D. (2011) Quantitative proteomics for investigating psychiatric disorders. Proteomics Clin Appl 5:38-49.
2010
- Filiou MD#, Bisle B, Reckow S, Teplytska L, Maccarrone G, Turck CW. (2010) Profiling of mouse synaptosome proteome and phosphoproteome by IEF. Electrophoresis 31:1294-301.
2009
- Haegler K, Mueller NS, Maccarrone G, Hunyadi-Gulyas E, Webhofer C, Filiou MD#, Zhang Y, Turck CW. (2009) QuantiSpec - Quantitative mass spectrometry data analysis of 15N-metabolically labeled proteins. J Proteomics 71:601-8.
- Frank E, Kessler MS, Filiou MD#, Zhang Y, Maccarrone G, Reckow S, Bunck M, Heumann H, Turck CW, Landgraf R, Hambsch B. (2009) Stable isotope metabolic labeling with a novel 15N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies. PLoS ONE 4:e7821.
- Durrenberger PF, Filiou MD#, Moran LB, Michael GJ, Novoselov S, Cheetham ME, Clark P, Pearce RK, Graeber MB. (2009) DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes. J Neurosci Res 87:238-45.
- Otte DM, Bilkei-Gorzó A, Filiou MD#, Turck CW, Yilmaz Ö, Holst MI, Schilling K, Abou-Jamra R, Schumacher J, Benzel I, Kunz WS, Beck H, Zimmer A. (2009) Behavioral changes in G72/G30 transgenic mice. Eur Neuropsychopharmacol 19:339-48.
- Zhang Y, Webhofer C, Reckow S, Filiou MD#, Maccarrone G, Turck CW. (2009) A MS data search method for improved 15N-labeled protein identification. Proteomics 9:4265-70.
