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Angeliki Magklara

Angeliki Magklara

Associate Professor of Clinical Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina
Email address
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Phone
+30 26510 07818
Fax
+30 2651 007077
 

Angeliki Magklara is an Αssociate Professor of Clinical Chemistry at the Department of Medicine, School of Health Sciences, University of Ioannina. She received her Bachelor's degree from the Department of Biology and her Master's degree in Clinical Biochemistry from the Department of Chemistry at the National and Kapodistrian University of Athens. She completed her PhD degree at the Department of Laboratory Medicine and Pathobiology at the University of Toronto in Canada, where she worked on the characterization of new members of the human kallikrein gene family and their evaluation as potential new tumor biomarkers. Dr. Magklara did her post-doctoral training at the Laboratory of Receptor Biology and Gene Expression at the National Institutes of Health (NCI/NIH) in Bethesda, Maryland, USA, where she worked on mechanisms of action of the progesterone receptor in breast cancer. Later on, she moved to the University of California in San Francisco (UCSF), where she worked on the mechanisms of epigenetic regulation of the olfactory receptor genes. In 2012 she was awarded a Marie Curie Career Integration Grant and she moved back to Greece, where she joined the Biomedical Research Institute of FORTH at Ioannina. In 2014, she assumed her academic position at the University of Ioannina. Her current research interests lie in the field of cancer epigenetics, cancer stem cells and liquid biopsies.

  1. Kordias D, Kostara CE,  Papadaki S,  Verigos J, Bairaktari E, Magklara A. Omics Analysis of Chemoresistant Triple Negative Breast Cancer Cells Reveals Novel Metabolic Vulnerabilities. Cells 2022;11(17):2719. doi: 10.3390/cells11172719.
  2. Papadaki S, Magklara A. Regulation of Metabolic Plasticity in Cancer Stem Cells and Implications in Cancer Therapy. Cancers(Basel) 2022;14(23):5912. doi:10.3390/ cancers14235912.
  3. Verigos J, Kordias D, Papadaki S, Magklara A. Transcriptional Profiling of Tumorspheres Reveals TRPM4 as a Novel Stemness Regulator in Breast Cancer. Biomedicines. 2021;9(10):1368. doi: 10.3390/biomedicines9101368.
  4. Verigos J, Karakaidos P, Kordias D, Papoudou-Bai A, Evangelou Z, Harissis HV, Klinakis A, Magklara A. The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program. Cancers 2019; 11(10).
  5. Kastrisiou M, Zarkavelis G, Kougioumtzi A, Sakaloglou P, Kostoulas C, Georgiou I, Batistatou A, Pentheroudakis G, Magklara A. Development and Validation of a Targeted 'Liquid' NGS Panel for Treatment Customization in Patients with Metastatic Colorectal Cancer. Diagnostics (Basel). 2021;11(12):2375. doi: 10.3390/diagnostics11122375.
  1. Papadaki S, Magklara A. Regulation of Metabolic Plasticity in Cancer Stem Cells and Implications in Cancer Therapy. Cancers(Basel) 2022;14(23):5912. doi:10.3390/ cancers14235912.
  2. Kordias D, Kostara CE,  Papadaki S,  Verigos J, Bairaktari E, Magklara A. Omics Analysis of Chemoresistant Triple Negative Breast Cancer Cells Reveals Novel Metabolic Vulnerabilities. Cells 2022;11(17):2719. doi: 10.3390/cells11172719.
  3. Georgakopoulou C, Thomos D, Tsolis T, Ypsilantis K, Plakatouras JC, Kordias D, Magklara A, Kouderis C, Kalampounias AG, Garoufis A. Synthesis, characterization, interactions with the DNA duplex dodecamer d(5'-CGCGAATTCGCG-3')2 and cytotoxicity of binuclear η6-arene-Ru(II) complexes. Dalton Trans 2022;51(36):13808-13825. doi: 10.1039/d2dt02304k.
  4. Iatridis N, Kougioumtzi A, Vlataki K, Papadaki S, Magklara A. Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener. 2022;27(4):1362. doi: 10.3390/molecules27041362.
  5. Kastrisiou M, Zarkavelis G, Kougioumtzi A, Sakaloglou P, Kostoulas C, Georgiou I, Batistatou A, Pentheroudakis G, Magklara A. Development and Validation of a Targeted 'Liquid' NGS Panel for Treatment Customization in Patients with Metastatic Colorectal Cancer. Diagnostics (Basel). 2021;11(12):2375. doi: 10.3390/diagnostics11122375.
  6. Verigos J, Kordias D, Papadaki S, Magklara A. Transcriptional Profiling of Tumorspheres Reveals TRPM4 as a Novel Stemness Regulator in Breast Cancer. Biomedicines. 2021;9(10):1368. doi: 10.3390/biomedicines9101368.
  7. Tsolis T, Nikolaou N, Ypsilantis K, Kougioumtzi A, Kordias D, Magklara A, Garoufis A. Synthesis, characterization, interactions with 9-MeG and cytotoxic activity of heterobimetallic RuII-PtII complexes bridged with 2, 2'-bipyrimidine. J Inorg Biochem. 2021;219:111435.
  8. Verigos J, Karakaidos P, Kordias D, Papoudou-Bai A, Evangelou Z, Harissis HV, Klinakis A, Magklara A. The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program. Cancers 2019; 11(10).
  9. Karakaidos P, Verigos I, Magklara A. LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target. Cancers 2019; 11(12).
  10. Kastrisiou M, Zarkavelis G, Pentheroudakis G, Magklara A. Clinical Application of Next-Generation Sequencing as A Liquid Biopsy Technique in Advanced Colorectal Cancer: A Trick or A Treat? Cancers 2019;11(10).
  11. Touloupi K, Küblbeck J, Magklara A, Molnár F, Reinisalo M, Konstandi, Honkakoski P, Pappas P The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression. Molecular Pharmacology 2019; 96(5): 655-663.
  12. Le Gros MA, Clowney EJ, Magklara A, Yen A, Markenscoff-Papadimitriou E, Colquitt B, Myllys M, Kellis M, Lomvardas S, Larabell CA. Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo. Cell Rep. 2016 Nov 15;17(8):2125-2136.
  13. Verigos J and Magklara A. Revealing the Complexity of Breast Cancer by Next Generation Sequencing. Cancers (Basel) 2015;7(4):2183-200.
  14. Lyons DB, Magklara A, Goh T, Sampath S, Schaefer A, Schotta G, Lomvardas S. Heterochromatin-Mediated Gene Silencing Facilitates the Diversification of Olfactory Neurons. Cell Rep.2014;9:1-9.
  15. Kougioumtzi A, Tsaparas P, Magklara A. Deep sequencing reveals new aspects of progesterone receptor signaling in breast cancer cells. PLoS One. 2014 Jun 4;9(6):e98404.
  16. Magklara A and Lomvardas S. Stochastic gene expression in mammals: Lessons from Olfaction. Trends in Cell Biology 2013 Sep;23(9):449-56.
  17. Johnson MA, Tsai L, Roy DS, Valenzuela DH, Mosley C, Magklara A, Lomvardas S, Liberles SD, Barnea G. Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13410-5.